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110429-45-3

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        • 110429-45-3 Structure

          110429-45-3 Structure
          IdentificationBack Directory
          [Name]

          Triethylene Glycol 2-Bromoethyl Methyl Ether
          [CAS]

          110429-45-3
          [Synonyms]

          mPEG4-Br
          m-PEG4-bromo
          m-PEG4-bromide
          Br-(CH2CH2O)4-Me
          Bromo-PEG4-methoxy
          Methyl-PEG4-bromide
          1-Bromo-3,6,9,12-tetraoxatridecane
          13-Bromo-2,5,8,11-tetraoxatridecane
          2,5,8,11-Tetraoxatridecane, 13-bromo-
          Triethylene Glycol 2-Bromoethyl Methyl Ether
          2-[2-[2-(2-Methoxyethoxy)ethoxy]ethoxy]ethyl Bromide
          2-[2-[2-(2-Methoxyethoxy)ethoxy]ethoxy]ethyl Bromide 1-Bromo-3,6,9,12-tetraoxatridecane
          [Molecular Formula]

          C9H19BrO4
          [MDL Number]

          MFCD12545963
          [MOL File]

          110429-45-3.mol
          [Molecular Weight]

          271.149
          Chemical PropertiesBack Directory
          [Boiling point ]

          296.3±25.0 °C(Predicted)
          [density ]

          1.256±0.06 g/cm3(Predicted)
          [refractive index ]

          1.4620 to 1.4660
          [storage temp. ]

          2-8°C
          [form ]

          clear liquid
          [color ]

          White to Yellow to Green
          [CAS DataBase Reference]

          110429-45-3
          Safety DataBack Directory
          [HS Code ]

          2909.19.6000
          Hazard InformationBack Directory
          [Description]

          m-PEG4-bromide is a PEG linker containing a bromide group. The bromide (Br) is a very good leaving group for nucleophilic substitution reactions. The hydrophilic PEG spacer increases solubility in aqueous media.
          [Biological Activity]

          Triethylene Glycol 2-Bromoethyl Methyl Ether is a cleavable ADC linker for the synthesis of antibody drug conjugates (ADCs) of trastuzumab (HY-P9907). It was placed distal to the monomethyl auristatin E (MMAE) payload to generate ADCs with altered hydrophilicity, antigen binding and in vitro potency. Tetraethylene glycol monotosylate can also be used as a linker of PROTAC, which can be used for the synthesis of PROTAC.
          [in vitro]

          ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

          [target]

          Cleavable

          PEGs

          Spectrum DetailBack Directory
          [Spectrum Detail]

          Triethylene Glycol 2-Bromoethyl Methyl Ether(110429-45-3)1HNMR
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