| Identification | Back Directory | [Name]
N-(4-fluorophenyl)quinolin-4-amine | [CAS]
1111618-71-3 | [Synonyms]
N-(4-fluorophenyl)quinolin-4-amine
4-Quinolinamine, N-(4-fluorophenyl)- | [Molecular Formula]
C15H11FN2 | [MOL File]
1111618-71-3.mol | [Molecular Weight]
238.26 |
| Hazard Information | Back Directory | [Synthesis]
N-(4-fluorophenyl)quinolin-4-amine was prepared by the reaction of 4-fluoroaniline with 4-chloroquinoline ethanol solution under microwave irradiation at 165°C.To a solution of 4-chloroquinoline (200 mg, 1.22 mmol) in ethanol (3 ml), 4- fluoroaniline (678 mg, 6.10 mmol) was added and the mixture was reacted at 165 °C for 3 hours under microwave radiation. The reaction mixture was aqueous sodium carbonate (20 ml) was added and this was then extracted using dichloromethane (3×25 ml). The organic extracts were collected, dried using magnesium sulphate, concentrated in vacuo and the resulting residue was purified by flash column chromatography eluting with 5% methanol in dichloromethane to give the title compound as a colourless solid (50 mg, 17%). |
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