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1126366-28-6

1126366-28-6 Structure

1126366-28-6 Structure
IdentificationBack Directory
[Name]

N-[5-(1H-imidazol-2-yl)-2,4-dimethylphenyl]-4-[(pyridin-2-yl)methoxy]benzamide
[CAS]

1126366-28-6
[Synonyms]

AZD7254
Benzamide, N-[5-(1H-imidazol-2-yl)-2,4-dimethylphenyl]-4-(2-pyridinylmethoxy)-
N-[5-(1H-imidazol-2-yl)-2,4-dimethylphenyl]-4-[(pyridin-2-yl)methoxy]benzamide
[EINECS(EC#)]

682-708-5
[Molecular Formula]

C24H22N4O2
[MOL File]

1126366-28-6.mol
[Molecular Weight]

398.46
Chemical PropertiesBack Directory
[Boiling point ]

577.5±50.0 °C(Predicted)
[density ]

1.262±0.06 g/cm3(Predicted)
[pka]

13.33±0.31(Predicted)
Hazard InformationBack Directory
[Uses]

AZD7254 is an orally active Smoothened (SMO) inhibitor with an EC50 of 1.0 nM against sonic Hh protein (shh)[1].
[in vivo]

AZD7254 (40 mg/kg; p.o.; twice daily for 10 days) exhibits 42% tumor growth inhibition in an HT29-MEF (murine embryonic fibroblast) co-implant xenograft model[1].

[References]

[1] Yang B, et al. Heteroarylamide smoothened inhibitors: Discovery of N-[2,4-dimethyl-5-(1-methylimidazol-4-yl)phenyl]-4-(2-pyridylmethoxy)benzamide (AZD8542) and N-[5-(1H-imidazol-2-yl)-2,4-dimethyl-phenyl]-4-(2- pyridylmethoxy)benzamide (AZD7254). Bioorg M DOI:10.1016/j.bmc.2019.115227
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