| Identification | Back Directory | [Name]
IMIPRAMINE-D3 HYDROCHLORIDE 98 ATOM % D | [CAS]
112898-42-7 | [Synonyms]
Imipramine-d3 hydrochloride
[2H3]-Imipramine hydrochloride
2H3]-Imipramine hydrochloride salt
IMIPRAMINE-D3 HYDROCHLORIDE 98 ATOM % D
10,11-Dihydro-N-methyl-N-(methyl-d3)-5H-dibenz[b,f]azepine-5-propanamine | [Molecular Formula]
C19H25ClN2 | [MDL Number]
MFCD00070405 | [MOL File]
112898-42-7.mol | [Molecular Weight]
316.87 |
| Hazard Information | Back Directory | [Uses]
Imipramine-d3 (hydrochloride) is deuterium labeled Imipramine (hydrochloride). Imipramine is an orally active tertiary amine tricyclic antidepressant. Imipramine is a Fascin1 inhibitor with antitumor activities. Imipramine also inhibits serotonin transporter with an IC50 value of 32 nM. Imipramine stimulates U-87MG glioma cells autophagy and induces HL-60 cell apoptosis. Imipramine shows neuroprotective and immunomodulatory effects[1][2][3][4][5][6]. | [References]
[1] Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. DOI:10.1177/1060028018797110
[2] Alburquerque-González B, et al. New role of the antidepressant imipramine as a Fascin1 inhibitor in colorectal cancer cells. Exp Mol Med. 2020 Feb;52(2):281-292. DOI:10.1038/s12276-020-0389-x
[3] Jeon SH, et al. The tricyclic antidepressant imipramine induces autophagic cell death in U-87MG glioma cells. Biochem Biophys Res Commun. 2011 Sep 23;413(2):311-7. DOI:10.1016/j.bbrc.2011.08.093
[4] Xia Z, et al. The antidepressants imipramine, clomipramine, and citalopram induce apoptosis in human acute myeloid leukemia HL-60 cells via caspase-3 activation. J Biochem Mol Toxicol. 1999;13(6):338-47. DOI:10.1002/(sici)1099-0461(1999)13:63.0.co;2-7
[5] Ramirez K, et al. Imipramine attenuates neuroinflammatory signaling and reverses stress-induced social avoidance. Brain Behav Immun. 2015 May;46:212-20. DOI:10.1016/j.bbi.2015.01.016
[6] Balkovetz DF, et al. Evidence for an imipramine-sensitive serotonin transporter in human placental brush-border membranes. J Biol Chem. 1989 Feb 5;264(4):2195-8. PMID:2914900 |
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