| Identification | Back Directory | [Name]
2,4-Thiazolidinedione, 5-[[5-(4-fluoro-2-hydroxyphenyl)-2-furanyl]Methylene]- | [CAS]
1138220-19-5 | [Synonyms]
5-((5-(4-Fluoro-2-hydroxyphenyl)furan-2-yl)methylene)thiazolidine-2,4-dione
2,4-Thiazolidinedione, 5-[[5-(4-fluoro-2-hydroxyphenyl)-2-furanyl]Methylene]- | [Molecular Formula]
C14H8FNO4S | [MOL File]
1138220-19-5.mol | [Molecular Weight]
305.28 |
| Hazard Information | Back Directory | [Uses]
A cell-permeable furanyl-thiazolidinedione compound that acts as a potent, ATP-competitive inhibitor of PI 3-Kγ and CKII (IC50 = 20 nM). It inhibits other PI 3-K isotypes (IC50 = 0.94, 20, and 20 μM for α, β, δ, respectively) and MKK7β (IC50 >10 μM) only at much higher concentrations and exhibits little activity against 77 other commonly studied kinases even at concentrations as high as 10 μM. Shown to inhibit stimulated Akt phosphorylation in cells in vitro and offer blockage of thioglycollate-induced neutrophil recruitment in a murine peritonitis model in vivo. | [Definition]
ChEBI: 5-[[5-(4-fluoro-2-hydroxyphenyl)-2-furanyl]methylidene]thiazolidine-2,4-dione is a halophenol and an organofluorine compound. |
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| Company Name: |
Merck KGaA
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| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
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