| Identification | Back Directory | [Name]
Tubulin Polymerization Inhibitor II | [CAS]
1151995-69-5 | [Synonyms]
Tubulin inhibitor 9
Tubulin Polymerization Inhibitor II
2H-Indol-2-one, 1,3-dihydro-6-methoxy-3-[(3,4,5-trimethoxyphenyl)methylene]- | [Molecular Formula]
C19H19NO5 | [MOL File]
1151995-69-5.mol | [Molecular Weight]
341.36 |
| Chemical Properties | Back Directory | [Boiling point ]
549.5±50.0 °C(Predicted) | [density ]
1.241±0.06 g/cm3(Predicted) | [storage temp. ]
+2C to +8C | [solubility ]
DMSO: 10mg/mL | [form ]
Yellow solid | [pka]
12.16±0.20(Predicted) | [color ]
yellow |
| Hazard Information | Back Directory | [Uses]
Tubulin Polymerization Inhibitor II is a Tubulin inhibitor. | [General Description]
A cell-permeable, SU5416- (Cat. Nos. 676487 and 676498) derived combretastatin A-4 (Cat. No. 234200) analog that acts as an effective anti-microtubule agent (IC50 = 4.5 μM in inhibiting polymerization of purified porcine brain tubulin) and displays extremely potent anti-proliferative activity towards various cancer cell lines (GI50<10 nM for 46 lines among a 53 NCI panel tested). | [Biochem/physiol Actions]
Cell permeable: yes |
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