| Identification | Back Directory | [Name]
APNA | [CAS]
119520-58-0 | [Synonyms]
APNA
ARACHIDONOYL P-NITROANILINE
N-(4-NITROPHENYL)-5Z,8Z,11Z,14Z-EICOSATETRAENAMIDE
5,8,11,14-Eicosatetraenamide, N-(4-nitrophenyl)-, (5Z,8Z,11Z,14Z)- | [Molecular Formula]
C26H36N2O3 | [MDL Number]
MFCD05863941 | [MOL File]
119520-58-0.mol | [Molecular Weight]
424.58 |
| Hazard Information | Back Directory | [Description]
Arachidonoyl p-nitroaniline (ApNA) is one of several nitroaniline fatty acid amides which can be used to measure fatty acid amide hydrolase (FAAH) activity. FAAH is a relatively unselective enzyme in that it accepts a variety of amide head groups other than the ethanolamine of its nominal endogenous substrate anandamide (AEA; ). It also will hydrolyze fatty acid amides with fewer carbons and fewer double bonds than arachidonate. (See also Decanoyl p-Nitroaniline - Catalog No. 90349). Exposure of ApNA to FAAH activity results in the release of the yellow colorimetric dye p-nitroaniline (ε = 13,500 at 382 nm). This offers the potential for fast and convenient measurements of FAAH activity using a 96-well plate spectrophotometer. | [Uses]
Arachidonoyl p-Nitroaniline is a nitroaniline probe for FAAH activity. | [References]
[1] MATTHEW P. PATRICELLI Benjamin F C. Characterization and Manipulation of the Acyl Chain Selectivity of Fatty Acid Amide Hydrolase?[J]. Biochemistry Biochemistry, 2001, 40 20: 6107-6115. DOI: 10.1021/bi002578r |
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Energy Chemical
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Boao Pike
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www.biopike.cn |
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