| Identification | Back Directory | [Name]
2,4(1H,3H)-Pyrimidinedione, 1-[2,5-anhydro-4-C-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]-3-O-[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]-6-deoxy-α-L-mannofuranosyl]-5-methyl- | [CAS]
1197033-22-9 | [Synonyms]
S-cEt-T
S-cEt-T phosphoramidite
CET-5-Me-U Phosphoramidite
S-cEt-T-CE-Phosphoramidite
5'-ODMTcEtm5UPhosphoramiditeAmidite
5'-ODMT cEt m5U Phosphoramidite (Amidite)
2,4(1H,3H)-Pyrimidinedione, 1-[2,5-anhydro-4-C-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]-3-O-[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]-6-deoxy-α-L-mannofuranosyl]-5-methyl-
2,4(1H,3H)-Pyrimidinedione, 1-[2,5-anhydro-4-C-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]-3-O-[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]-6-deoxy-α-L-mannofuranosyl]-5-methyl- | [Molecular Formula]
C42H51N4O9P | [MOL File]
1197033-22-9.mol | [Molecular Weight]
786.86 |
| Hazard Information | Back Directory | [Uses]
5'-ODMT cEt m5U Phosphoramidite Amidite is a locked nucleic acid (LNA) analog. 5'-ODMT cEt m5U Phosphoramidite Amidite shows excellent safety and antisense activity in mice[1][2]. | [References]
[1] Fiona J. Laraman, et al. Investigating the Activation Kinetics of Phosphoramidites for Oligonucleotide Synthesis. Org. Process Res. Dev. 2022, 26, 3, 764-772.
[2] Vasquez G, et al. Site-specific incorporation of 5'-methyl DNA enhances the therapeutic profile of gapmer ASOs. Nucleic Acids Res. 2021 Feb 26;49(4):1828-1839. DOI:10.1093/nar/gkab047 |
|
| Company Name: |
Asymchem Labs.
|
| Tel: |
17347534561 |
| Website: |
https://www.asymchem.com.cn/ |
|