| Identification | Back Directory | [Name]
6-Amino-N-cyclohexyl-N,3-dimethyl-thiazolo[3,2-a]benzimidazole-2-carboxamide hydrochloride | [CAS]
1216398-09-2 | [Synonyms]
3H]-YM 298198
YM-298198 hydrochloride >=98% (HPLC)
YM298198 hydrochloride, mGlu1 antagonist | [Molecular Formula]
C18H23ClN4OS | [MDL Number]
MFCD08703122 | [MOL File]
1216398-09-2.mol | [Molecular Weight]
378.92 |
| Chemical Properties | Back Directory | [storage temp. ]
2-8°C | [solubility ]
H2O: soluble5mg/mL, clear | [form ]
powder | [color ]
white to beige | [Water Solubility ]
Soluble to 100 mM in water | [InChI]
1S/C18H22N4OS.ClH/c1-11-16(17(23)21(2)13-6-4-3-5-7-13)24-18-20-14-9-8-12(19)10-15(14)22(11)18;/h8-10,13H,3-7,19H2,1-2H3;1H | [InChIKey]
WYTJVUVCSUWZTH-UHFFFAOYSA-N | [SMILES]
Cl.CN(C1CCCCC1)C(=O)c2sc3nc4ccc(N)cc4n3c2C |
| Hazard Information | Back Directory | [Uses]
YM 298198 Hydrochloride is a noncompetitive, high affinity, and selective antagonist of metabotropic glutamate receptor type 1 (mGluR-1). | [Biological Activity]
YM-298198 is an orally activenoncompetitive mGlu1 receptor antagonist. The compound inhibits glutamate-induced inositol phosphate production in NIH3T3 cells (IC50 = 16 nM). YM-298198 displays analgesic and antinociceptive properties in vivo. | [in vivo]
YM-298198 hydrochloride (30 mg/kg; p.o.) shows a significant analgesic effect in streptozotocin-induced hyperalgesic mice[1].
| Animal Model: | Male ICR mice[1] | | Dosage: | 30 mg/kg | | Administration: | Oral administration | | Result: | Prolonged nociceptive response latency in streptozotocin (200 mg/kg)-induced hyperalgesic mice. |
| [IC 50]
mGluR 1 |
|
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Energy Chemical
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http://www.energy-chemical.com |
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Merck KGaA
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21-20338288 |
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www.sigmaaldrich.cn |
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Abcam Limited
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www.abcam.cn |
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