| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
Acetonitrile:Methanol (1:1): Soluble,DMSO: Soluble, | [form ]
A solid | [Water Solubility ]
Water: Soluble |
| Hazard Information | Back Directory | [Biological Activity]
Fosinopril-d7 is intended for use as an internal standard for the quantification of fosinopril by GC- or LC-MS. Fosinopril is a prodrug form of the angiotensin-converting enzyme (ACE) inhibitor fosinoprilat.1 Oral administration of fosinopril inhibits angiotensin I-induced pressor responses in normotensive rats, dogs, and monkeys when administered at doses of 15, 15, and 10 μmol/kg, respectively. Fosinopril (2.5 mg/kg) reduces fractional shortening and decreases left ventricular size in a porcine model of congestive heart failure.2 Formulations containing fosinopril have been used in the treatment of hypertension and congestive heart failure. | [References]
1.DeForrest, J.M., Waldron, T.L., Harvey, C., et al.Fosinopril, a phosphinic acid inhibitor of angiotensin I converting enzyme: In vitro and preclinical in vivo pharmacologyJ. Cardiovasc. Pharmacol.14(5)730-736(1989)
2.McElmurray, J.H., III, Mukherjee, R., New, R.B., et al.Angiotensin-converting enzyme and matrix metalloproteinase inhibition with developing heart failure: Comparative effects on left ventricular function and geometryJ. Pharmacol. Exp. Ther.291(2)799-811(1999)
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| Company Name: |
ChemeGen
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| Tel: |
18818260767 |
| Website: |
https://www.chemegen.com |
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