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122510-61-6

122510-61-6 Structure

122510-61-6 Structure
IdentificationBack Directory
[Name]

4-Morpholinecarbothioic acid, 2-(2-pyrazinylcarbonyl)hydrazide
[CAS]

122510-61-6
[Synonyms]

AF615
N'-(morpholine-4-carbothioyl)pyrazine-2-carbohydrazide
4-Morpholinecarbothioic acid, 2-(2-pyrazinylcarbonyl)hydrazide
[Molecular Formula]

C10H13N5O2S
[MOL File]

122510-61-6.mol
[Molecular Weight]

267.31
Chemical PropertiesBack Directory
[Melting point ]

184-185 °C(Solv: methanol (67-56-1))
[density ]

1.398±0.06 g/cm3(Predicted)
[pka]

8.54±0.23(Predicted)
Hazard InformationBack Directory
[Uses]

AF615 is a small molecule inhibitor targeting the CDT1/Geminin protein complex (IC50 = 0.313 μM). AF615 selectively induces DNA damage, inhibits DNA synthesis, causes cell cycle arrest, and decreases the survival rate in cancer cell lines. AF615 displayed a Ki = 0.37 μM in case of Geminin-tCDT1 interaction and a Ki = 0.75 μM in case of Geminin-miniCDT1 interaction[1].
[References]

[1] Nikolaos Karantzelis, et al. Small Molecule Inhibitor Targeting CDT1/Geminin Protein Complex Promotes DNA Damage and Cell Death in Cancer Cells. Front Pharmacol. 2022 Apr 25;13:860682.
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