| Identification | Back Directory | [Name]
Benzamide, N-[4-[(1R,2S)-2-aminocyclopropyl]phenyl]-, rel- | [CAS]
1228143-76-7 | [Synonyms]
LSD1-IN-12
Benzamide, N-[4-[(1R,2S)-2-aminocyclopropyl]phenyl]-, rel- | [Molecular Formula]
C16H16N2O | [MOL File]
1228143-76-7.mol | [Molecular Weight]
252.31 |
| Hazard Information | Back Directory | [Uses]
LSD1-IN-12 (compound 2) is a potent LSD1 inhibitor, with Ki values of 1.1 μM (LSD1), 61 μM (LSD2), 2.3 μM (MAO-A), and 3.5 μM (MAO-B), respectively[1]. | [IC 50]
MAO-A: 2.3 μM (Ki); MAO-B: 3.5 μM (Ki) | [References]
[1] Li C, et al. Structure-Activity Relationship Study of Indolin-5-yl-cyclopropanamine Derivatives as Selective Lysine Specific Demethylase 1 (LSD1) Inhibitors. J Med Chem. 2022 Mar 10;65(5):4335-4349. DOI:10.1021/acs.jmedchem.1c02156 |
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