ChemicalBook--->CAS DataBase List--->1233748-60-1

1233748-60-1

1233748-60-1 Structure

1233748-60-1 Structure
IdentificationBack Directory
[Name]

(Z)-GW 5074
[CAS]

1233748-60-1
[Synonyms]

(Z)-GW 5074
2H-Indol-2-one, 3-[(3,5-dibromo-4-hydroxyphenyl)methylene]-1,3-dihydro-5-iodo-, (3Z)-
[Molecular Formula]

C15H8Br2INO2
[MOL File]

1233748-60-1.mol
[Molecular Weight]

520.94
Chemical PropertiesBack Directory
[Boiling point ]

561.4±50.0 °C(Predicted)
[density ]

2.248±0.06 g/cm3(Predicted)
[pka]

6.15±0.40(Predicted)
Hazard InformationBack Directory
[Uses]

(Z)-GW 5074 is a compound which interacts with both mHTT (mutant huntingtin protein) and LC3, but not but not with the wild-type HTT protein. (Z)-GW 5074 inhibits c-Raf, shows no effect on autophagy, and is effective for neurodegenerative disorder[1].
[IC 50]

c-Raf
[References]

[1] Li Z, et al. Allele-selective lowering of mutant HTT protein by HTT-LC3 linker compounds. Nature. 2019 Oct 30. DOI:10.1038/s41586-019-1722-1
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