| Identification | Back Directory | [Name]
DBCO-PEG4-amine | [CAS]
1255942-08-5 | [Synonyms]
DBCO-PEG4-NH2 DBCO-PEG4-amine DBCO-NHCOPEG4-amine DBCO-NH-PEG4-CH2CH2NH2 DBCO-NHCO-PEG4-amine TFA salt Azadibenzocyclooctyne-PEG4-amine DBCO-PEG4 amine
(ADIBO-PEG4-amine) 4,7,10,13-Tetraoxapentadecanamide, 15-amino-N-[3-(11,12-didehydrodibenz[b,f]azocin-5(6H)-yl)-3-oxopropyl]- 3-[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethoxy]-N-[3-(2-azatricyclo[10.4.0.04,9]hexadeca-1(16),4,6,8,12,14-hexaen-10-yn-2-yl)-3-oxopropyl]propanamide | [Molecular Formula]
C29H37N3O6 | [MDL Number]
MFCD22380748 | [MOL File]
1255942-08-5.mol | [Molecular Weight]
523.62 |
| Chemical Properties | Back Directory | [Boiling point ]
784.1±60.0 °C(Predicted) | [density ]
1.23±0.1 g/cm3(Predicted) | [storage temp. ]
-20°C Freezer, Under inert atmosphere | [solubility ]
Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly) | [form ]
Solid | [pka]
15.14±0.46(Predicted) | [color ]
Yellow to Dark Yellow | [Water Solubility ]
Soluble in water. | [InChIKey]
MRRSYYMIRSTYMO-UHFFFAOYSA-N | [SMILES]
O=C(NCCC(=O)N1C=2C=CC=CC2C#CC=3C=CC=CC3C1)CCOCCOCCOCCOCCN |
| Hazard Information | Back Directory | [Description]
DBCO-NHCO-PEG4-amine is a carboxyl-reactive building block with extended PEG spacer arm. The hydrophilic PEG spacer arm improves water solubility. In the presence of of activators (e.g. EDC, or HATU), this reagent can be used to derivatize carboxyl groups or activated esters (e.g. The NHS ester) through a stable amide bond. DBCO is commonly used for copper-free Click Chemistry reactions. | [Biological Activity]
DBCO-NHCO-PEG4-amine is a PROTAC linker and belongs to the PEG class. It is a cleavable ADC linker that can be used to link MMAE (HY-15162) to antibodies such as DBCO-VCpAB-MMAE and DBCO-TRX-MMAE, with EC50 for SKBR3 cells, respectively 280 nM and 22 nM). | [in vitro]
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker. | [target]
|
|
|
Tags:1255942-08-5
Related Product Information
|
|
4342-03-4
209984-56-5
1395786-30-7
1537170-85-6
2093409-57-3
1480516-75-3
2093197-94-3
1255942-07-4
1255942-06-3
|
庆城县|
文山县|
广昌县|
岑巩县|
沙雅县|
兴仁县|
任丘市|
石屏县|
黔江区|
沂南县|
定西市|
于田县|
通州市|
应城市|
兴安县|
堆龙德庆县|
双桥区|
唐山市|
闽清县|
昭平县|
南宁市|
陆河县|
云安县|
木兰县|
绍兴县|
班玛县|
武宣县|
绥芬河市|
新蔡县|
陆丰市|
稷山县|
兴隆县|
墨竹工卡县|
湖北省|
布尔津县|
东兰县|
和顺县|
富蕴县|
高密市|
晋州市|
思茅市|
|