| Identification | Back Directory | [Name]
Px-104 | [CAS]
1268244-88-7 | [Synonyms]
(-)-PX-104
(-)-PX-102 trans isomer
(-)-PX20606 TRANS ISOMER
PX-104; PX104; PX 104; PX-102; PX102; PX 102
( ) PX20606 trans isomer,(-)-PX-20606 trans isomer,()PX20606 trans isomer | [Molecular Formula]
C29H22Cl3NO4 | [MOL File]
1268244-88-7.mol | [Molecular Weight]
554.85 |
| Chemical Properties | Back Directory | [Boiling point ]
690.1±55.0 °C(Predicted) | [density ]
1.444±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Ethanol : ≥ 50 mg/mL (90.11 mM) | [form ]
Solid | [pka]
4.35±0.10(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
(R,R)-PX20606 is a FXR agonist with EC50s of 18 and 29 nM for FXR in FRET and M1H assay, respectively. | [storage]
Store at -20°C | [References]
[1] Kinzel O, et al. Novel substituted isoxazole FXR agonists with cyclopropyl, hydroxycyclobutyl and hydroxyazetidinyl linkers: Understanding and improving key determinants of pharmacological properties. Bioorg Med Chem Lett. 2016 Aug 1;26(15):3746-53. DOI:10.1016/j.bmcl.2016.05.070 |
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