| Identification | Back Directory | [Name]
(2S)-1-[(2S)-2-[(1-carboxy-3-phenyl-propyl)amino]-6-[6-[5-[(1S,2S,5R)- 7-oxo-3-thia-6,8-diazabicyclo[3.3.0]oct-2-yl]pentanoylamino]hexanoylam ino]hexanoyl]pyrrolidine-2-carboxylic acid | [CAS]
130007-47-5 | [Synonyms]
BL 11
(2S)-1-[(2S)-2-[(1-carboxy-3-phenyl-propyl)amino]-6-[6-[5-[(1S,2S,5R)- 7-oxo-3-thia-6,8-diazabicyclo[3.3.0]oct-2-yl]pentanoylamino]hexanoylam ino]hexanoyl]pyrrolidine-2-carboxylic acid | [Molecular Formula]
C37H56N6O8S | [MOL File]
130007-47-5.mol |
| Hazard Information | Back Directory | [Description]
Lisinopril, epsilon-biotinamidocaproyl- is an angiotensin converting enzyme (ACE) inhibitor. | [Uses]
ε-Biotinamidocaproyl-β-alanyl-β-alanyl-lisinopril is an angiotensin-converting enzyme (ACE) inhibitor. Structurally, ε-Biotinamidocaproyl-β-alanyl-β-alanyl-lisinopril is a biotinylated derivative of lisinopril (HY-18206), with a chemical structure linking the biotin molecule and the lisinopril molecule composed of 19 atoms. ε-Biotinamidocaproyl-β-alanyl-β-alanyl-lisinopril can bind to both ACE and streptavidin (HY-P3152) simultaneously, making it possible to separate and purify ACE using streptavidin-agarose beads[1]. | [References]
[1] Bernstein KE, et al. A deeply recessed active site in angiotensin-converting enzyme is indicated from the binding characteristics of biotin-spacer-inhibitor reagents. Biochem Biophys Res Commun. 1990 Feb 28;167(1):310-6. DOI:10.1016/0006-291x(90)91766-l |
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