| Identification | Back Directory | [Name]
Izilendustat hydrochloride | [CAS]
1303513-80-5 | [Synonyms]
Izilendustat hydrochloride
1-Piperazinecarboxylic acid, 4-[[1-[(4-chlorophenyl)methyl]-1,2-dihydro-3-hydroxy-2-oxo-4-pyridinyl]methyl]-, 1,1-dimethylethyl ester, hydrochloride (1:1) | [MOL File]
1303513-80-5.mol | [Molecular Weight]
470.39 |
| Hazard Information | Back Directory | [Uses]
Izilendustat (hydrochloride) is a potent inhibitor of prolyl hydroxylase which stabilizes hypoxia inducible factor- 1 alpha (HIF- lα), as well as hypoxia inducible factor-2 (HIF-2). Izilendustat (hydrochloride) has the potential for the research of HIF- lα related diseases including Peripheral Vascular Disease (PVD), Coronary Artery Disease (CAD), heart failure, ischemia, anemia, colitis, and other inflammatory bowel diseases (extracted from patent WO2011057115A1/WO2011057112A1/WO2011057121A1)[1][2][3]. | [References]
[1] Joseph H, et al. Prolyl hydroxylase inhibitors. Patent WO2011057115A1.
[2] Robert Shalwitz, et al. Methods for increasing the stabilization of hypoxia inducible factor-1 alpha. Patent WO2011057112A1.
[3] Joseph H, et al. Compositions and methods for treating colitis. Patent WO2011057121A1. |
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