| Identification | Back Directory | [Name]
1207629-49-9 (free) | [CAS]
1325212-97-2 | [Synonyms]
1207629-49-9 (free)
GSK-2245035 maleate
GSK-2245035 1325212-97-2 | [Molecular Formula]
C24H38N6O6 | [MOL File]
1325212-97-2.mol | [Molecular Weight]
506.6 |
| Hazard Information | Back Directory | [Uses]
GSK2245035 maleate is a highly potent and selective intranasal Toll-Like receptor 7 (TLR7) agonist with preferential Type-1 interferon (IFN)-stimulating properties. GSK2245035 maleate has pEC50s of 9.3 and 6.5 for IFNα and TFNα. GSK2245035 maleate effectively suppresses allergen-induced Th2 cytokine production in human peripheral blood cell cultures. GSK2245035 maleate is used for asthma[1]. | [References]
[1] Biggadike K, et al. Discovery of 6-Amino-2-{[(1S)-1-methylbutyl]oxy}-9-[5-(1-piperidinyl)pentyl]-7,9-dihydro-8H-purin-8-one (GSK2245035), a Highly Potent and Selective Intranasal Toll-Like Receptor 7 Agonist for the Treatment of Asthma. J Med Chem. 2016 Mar 10;59(5):1711-26. DOI:10.1021/acs.jmedchem.5b01647 |
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