| Identification | Back Directory | [Name]
1H-Imidazole-2-methanamine, N-(2-bromophenyl)-5-(6-methyl-2-pyridinyl)-4-[1,2,4]triazolo[1,5-a]pyridin-6-yl- | [CAS]
1352608-94-6 | [Synonyms]
N-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methyl)-2-bromoaniline
1H-Imidazole-2-methanamine, N-(2-bromophenyl)-5-(6-methyl-2-pyridinyl)-4-[1,2,4]triazolo[1,5-a]pyridin-6-yl-
N-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methyl)-2-bromoaniline, 10 mM in DMSO
N((4([1,2,4]triazolo[1,5a]pyridin6yl)5(6methylpyridin2yl)1Himidazol2yl)methyl)2bromoaniline,N ((4 ([1,2,4]triazolo[1,5 a]pyridin 6 yl) 5 (6 methylpyridin 2 yl) 1H imidazol 2 yl)methyl) 2 bromoaniline | [Molecular Formula]
C22H18BrN7 | [MOL File]
1352608-94-6.mol | [Molecular Weight]
460.33 |
| Hazard Information | Back Directory | [Uses]
ALK5-IN-10 (Compound 5d) is a TGF-β type I receptor kinase ALK5 inhibitor, with IC50s of 0.007 and 1.98 μM for ALK5 and p38α, respectively. ALK5-IN-10 can be used for the research of cancer[1]. | [References]
[1] Jin C H, et al. Discovery of N-((4-([1, 2, 4] Triazolo [1, 5-a] Pyridin-6-Yl)-5-(6-Methylpyridin-2-Yl)-1 H-Imidazol-2-Yl) methyl)-2-Fluoroaniline (EW-7197): a highly potent, selective, and orally bioavailable inhibitor of TGF-β type I receptor kinase as cancer immunotherapeutic/antifibrotic agent. Journal of medicinal chemistry. 2014, 57(10): 4213-4238. |
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