| Identification | Back Directory | [Name]
C17 Lactosylceramide (d18:1/17:0) | [CAS]
1354699-26-5 | [Synonyms]
C17 Lactosylceramide (d18:1/17:0)
C17 Lactosyl(β) Ceramide (d18:1/17:0)
C17 Lactosyl(ss) Ceramide (d18:1/17:0)
C17 Lactosyl(beta) Ceramide (d18:1/17:0)
N-[(1S,2R,3E)-1-[[(4-O-β-D-galactopyranosyl-β-D-glucopyranosyl)oxy]methyl]-2-hydroxy-3-heptadecen-1-yl]-heptadecanamide
Heptadecanamide, N-[(1S,2R,3E)-1-[[(4-O-β-D-galactopyranosyl-β-D-glucopyranosyl)oxy]methyl]-2-hydroxy-3-heptadecen-1-yl]- | [Molecular Formula]
C47H89NO13 | [MOL File]
1354699-26-5.mol | [Molecular Weight]
876.22 |
| Chemical Properties | Back Directory | [Boiling point ]
995.4±65.0 °C(Predicted) | [density ]
1.15±0.1 g/cm3(Predicted) | [storage temp. ]
-20°C | [solubility ]
Chloroform:Methanol:Water (2:1:0.1): soluble | [form ]
A solid | [pka]
12.79±0.70(Predicted) | [InChIKey]
RXEAEJDDQFAFLW-NMZPIEEZSA-N | [SMILES]
[H][C@](/C=C/CCCCCCCCCCCCC)(O)[C@@]([H])(NC(CCCCCCCCCCCCCCCC)=O)CO[C@H](O1)[C@H](O)[C@@H](O)[C@@H]([C@H]1CO)O[C@H](O2)[C@H](O)[C@@H](O)[C@H]([C@H]2CO)O |
| Hazard Information | Back Directory | [Description]
C17 Lactosylceramide is a naturally occurring sphingolipid that has been found in human brain metastases of lung adenocarcinomas but not in healthy brain tissue. [Matreya, LLC. Catalog No. 1538] | [General Description]
Lactosylceramide (LacCer) is a glycosphingolipid. It consists of a hydrophobic?ceramide?lipid and a hydrophilic sugar moiety. LacCer is expressed abundantly in the nervous system and myelin sheath. | [Biochem/physiol Actions]
Lactosylceramide (LacCer) is a structural and signaling lipid. It is implicated in signal transduction, cell adhesion and host-tissue pathogen interactions. LacCer modulates cell proliferation and apoptosis. It is involved in regulating cellular stress response and microbial pathogenesis. LacCer regulates innate immune responses. It helps in microbial attachment and also acts as an adhesion receptor for pathogens. | [References]
[1] ALINA D. ZAMFIR. Assessment of the Molecular Expression and Structure of Gangliosides in Brain Metastasis of Lung Adenocarcinoma by an Advanced Approach Based on Fully Automated Chip-Nanoelectrospray Mass Spectrometry[J]. Journal of the American Society for Mass Spectrometry, 2011, 22 12: 2145-2159. DOI: 10.1007/s13361-011-0250-5 |
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