| Identification | Back Directory | [Name]
Benzamide, N-[2-[(3S)-3-[[cis-4-hydroxy-4-[5-(2-pyrimidinyl)-2-pyridinyl]cyclohexyl]amino]-1-pyrrolidinyl]-2-oxoethyl]-3-(trifluoromethyl)- | [CAS]
1372407-07-2 | [Synonyms]
(s)-PF-4136309
N-[2-[(3S)-3-[[cis-4-hydroxy-4-(5-pyrimidin-2-yl-2-pyridyl)cyclohexyl]amino]pyrrolidin-1-yl]-2-oxo-ethyl]-3-(trifluoromethyl)benzamide
N-{2-[(3S)-3-({cis-4-Hydroxy-4-[5-(2-pyrimidinyl)-2-pyridinyl]cyclohexyl}amino)-1-pyrrolidinyl
]-2-oxoethyl}-3-(trifluoromethyl)benzamide
Benzamide, N-[2-[(3S)-3-[[cis-4-hydroxy-4-[5-(2-pyrimidinyl)-2-pyridinyl]cyclohexyl]amino]-1-pyrrolidinyl]-2-oxoethyl]-3-(trifluoromethyl)- | [Molecular Formula]
C29H31F3N6O3 | [MOL File]
1372407-07-2.mol | [Molecular Weight]
568.59 |
| Chemical Properties | Back Directory | [Boiling point ]
712.2±60.0 °C(Predicted) | [density ]
1.40±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
13.17±0.46(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
(s)-PF-4136309 is the isomer of PF-4136309 (HY-13245), and can be used as an experimental control. PF-4136309 is a potent, selective, and orally bioavailable CCR2 antagonist, with IC50s of 5.2 nM, 17 nM and 13 nM for human, mouse and rat CCR2. | [References]
[1] Xue CB, et al. Discovery of INCB8761/PF-4136309, a Potent, Selective, and Orally Bioavailable CCR2 Antagonist. ACS Med. Chem. Lett., 2011, 2 (12), pp 913-918. DOI:10.1021/ml200199c |
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| Company Name: |
Elucigen bio
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| Tel: |
13501719342; 13501719342 |
| Website: |
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