| Identification | Back Directory | [Name]
1-[4-amino-7-[3-(2-methoxyethylamino)propyl]-5-(4-methylphenyl)pyrrolo[2,3-d]pyrimidin-6-yl]-2-fluoroethanone | [CAS]
1414811-15-6 | [Synonyms]
FMK-MEA
1-[4-amino-7-[3-(2-methoxyethylamino)propyl]-5-(4-methylphenyl)pyrrolo[2,3-d]pyrimidin-6-yl]-2-fluoroethanone
Ethanone, 1-[4-amino-7-[3-[(2-methoxyethyl)amino]propyl]-5-(4-methylphenyl)-7H-pyrrolo[2,3-d]pyrimidin-6-yl]-2-fluoro- | [Molecular Formula]
C21H26FN5O2 | [MDL Number]
MFCD27989271 | [MOL File]
1414811-15-6.mol | [Molecular Weight]
399.462 |
| Hazard Information | Back Directory | [Description]
FMK-MEA is a potent and selective p90 Ribosomal S6 Kinase (RSK) inhibitor. | [Uses]
FMK-MEA is a potent and selective p90 Ribosomal S6 Kinase (RSK) inhibitor. | [Definition]
ChEBI: 1-[4-amino-7-[3-(2-methoxyethylamino)propyl]-5-(4-methylphenyl)-6-pyrrolo[2,3-d]pyrimidinyl]-2-fluoroethanone is a member of pyrroles. | [in vivo]
FMK-MEA treatment (80 mg/kg/day for 16 days by intraperitoneal injection) in highly metastatic M4e cell xenograft nude mice results in a significant attenuation of LN metastasis. FMK-MEA treatment has no effect on the tumor size, and the proliferation rate of the primary tumor[1]. | [IC 50]
RSK2 | [References]
[1] Li D, et al. The prometastatic ribosomal S6 kinase 2-cAMP response element-binding protein (RSK2-CREB) signaling pathway up-regulates the actin-binding protein fascin-1 to promote tumor metastasis. J Biol Chem. 2013 Nov 8;288(45):32528-38. DOI:10.1074/jbc.M113.500561 |
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