| Hazard Information | Back Directory | [Uses]
HDAC4-IN-1 (compound 1a) is a class IIa HDACI inhibitor (IC50=0.077 μM). HDAC4-IN-1 can enhance Caspase-induced Apoptosis. HDAC4-IN-1 has anticancer activity. HDAC4-IN-1 can be used in the research of drug combination against cancer[1]. | [IC 50]
HDAC2: 6.13 μM (IC50); HDAC4: 0.012 μM (IC50); HDAC6: 5.79 μM (IC50); HDAC8: 4.26 μM (IC50) | [References]
[1] Asfaha Y, et al. 5-(Trifluoromethyl)-1,2,4-oxadiazole (TFMO)-based highly selective class IIa HDAC inhibitors exhibit synergistic anticancer activity in combination with bortezomib. Eur J Med Chem. 2023 Nov 10;263:115907. DOI:10.1016/j.ejmech.2023.115907 |
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