| Identification | Back Directory | [Name]
7-Diethylamino-3-formyl-4-(4’-methoxyphenyl)coumarin | [CAS]
1428730-05-5 | [Synonyms]
NeuroSensor 521
NeuroSensor 521 >=98% (HPLC)
7-Diethylamino-3-formyl-4-(4’-methoxyphenyl)coumarin
7-(Diethylamino)-4-(4-methoxyphenyl)-2-oxo-2H-1-benzopyran-3-carboxaldehyde
2H-1-Benzopyran-3-carboxaldehyde, 7-(diethylamino)-4-(4-methoxyphenyl)-2-oxo- | [Molecular Formula]
C21H21NO4 | [MOL File]
1428730-05-5.mol | [Molecular Weight]
351.4 |
| Chemical Properties | Back Directory | [Boiling point ]
557.2±50.0 °C(Predicted) | [density ]
1.260±0.06 g/cm3(Predicted) | [storage temp. ]
-70°C | [solubility ]
DMSO: soluble10mg/mL, clear | [form ]
powder | [pka]
2.78±0.20(Predicted) | [color ]
yellow to orange |
| Hazard Information | Back Directory | [Description]
Neurosensor 521 is a selective noradrenalin and dopamine fluorescent indicator. It acts by binding catecholamines such as dopamine and norepinephrine more tightly than other biogenic amines such as glutamate, and does not interact with secondary amines such as epinephrine. | [Uses]
Neurosensor 521 is a selective noradrenalin and dopamine fluorescent indicator. | [Biochem/physiol Actions]
NeuroSensor 521 is a fluorescent turn-on sensor designed for the selective visualization of norepinephrine over epinephrine in fixed and live cells and the fluorescence is not affected by fixation. NeuroSensor 521 binds to all primary amines, but binds catecholamines such as dopamine and norepinephrine more tightly than other biogenic amines such as glutamate and does not interact with secondary amines such as epinephrine. Because of the spectral properties of NeuroSensor 521, the unbound and bound states can be monitored using 440 and 488 nm excitation, respectively. In chromaffin cells NeuroSensor 521 stained the norepinephrine-containing cells preferentially over epinephrine-containing cells under identical conditions. | [Excitation / Emission Maximum]
488 nm/521 nm |
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Sigma-Aldrich
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Energy Chemical
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http://www.energy-chemical.com |
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Merck KGaA
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www.sigmaaldrich.cn |
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