| Identification | Back Directory | [Name]
[1,4'-Bipiperidine]-1'-ethanol, α-[[4-(trifluoromethyl)phenoxy]methyl]-, (αS)- | [CAS]
1440532-32-0 | [Synonyms]
TWIK-1/TREK-1-IN-2
[1,4'-Bipiperidine]-1'-ethanol, α-[[4-(trifluoromethyl)phenoxy]methyl]-, (αS)- | [Molecular Formula]
C20H29F3N2O2 | [MOL File]
1440532-32-0.mol | [Molecular Weight]
386.45 |
| Hazard Information | Back Directory | [Uses]
TWIK-1/TREK-1-IN-2 (Compound 2g) is a TWIK-1/TREK-1 inhibitor. TWIK-1/TREK-1-IN-2 inhibits TREK-1 homodimer and TWIK-1/TREK-1 heterodimer with IC50s of 10.13 μM and 15.5 μM. TWIK-1/TREK-1-IN-2 is an antidepressant[1]. | [References]
[1] Lee EH, et al. Novel potent blockers for TWIK-1/TREK-1 heterodimers as potential antidepressants. Biomed Pharmacother. 2023 Sep;165:115139. DOI:10.1016/j.biopha.2023.115139 |
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