| Identification | Back Directory | [Name]
M-2912 | [CAS]
1460285-69-1 | [Synonyms]
M-2912
Tankyrase-IN-5
Pyrrolo[1,2-a]pyrazin-1(2H)-one, 3-[4-(1-hydroxy-1-methylethyl)phenyl]-7-methyl- | [Molecular Formula]
C17H18N2O2 | [MOL File]
1460285-69-1.mol | [Molecular Weight]
282.34 |
| Hazard Information | Back Directory | [Uses]
Tankyrase-IN-5 (Compound 30f), an analogue of MSC2504877 (HY-123851), is a tankyrase TNKS1 and TNKS2 inhibitor with IC50s of 2.3 nM and 7.9 nM, respectively[1]. | [References]
[1] Buchstaller HP, et al. Optimization of a Screening Hit toward M2912, an Oral Tankyrase Inhibitor with Antitumor Activity in Colorectal Cancer Models. J Med Chem. 2021 Jul 22;64(14):10371-10392. DOI:10.1021/acs.jmedchem.1c00800 |
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