| Identification | Back Directory | [Name]
Fibronectin type III repeat-containing protein 2 (cleaved) | [CAS]
NoCAS | [Synonyms]
CD121a
Irisin
Fibronectin type III domain-containing protein 5 (cleaved)
Fibronectin type III repeat-containing protein 2 (cleaved) |
| Hazard Information | Back Directory | [Uses]
Irisin is an described exercise-induced hormone secreted by skeletal muscle in mice and humans. Irisin is cleaved from the type I membrane protein FNDC5 (fibronectin type III domain containing 5). FNDC5 is mainly expressed in the muscles. Low levels of the mRNA are also present in the kidney, liver and lung. The gene encoding irisin is mapped to human chromosome 1p35.1. | [Biological Activity]
Irisin activates beige f at cells (beige cells have a gene expression pattern distinct from either white or brown f at and are preferentially sensitive to the polypeptide hormone Irisin) and improves systemic metabolism by increasing energy expenditure. It is mainly responsible for the conversion of white f at into brown fat. This conversion enhances metabolic uncoupling and caloric expenditure. Irisin is always associated with beneficial responses of exercise on cellular metabolism. In obese and type 2 diabetic patientslow levels of circulating irisin are characteristic of the adipose tissue and muscle. |
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Merck KGaA
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21-20338288 |
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www.sigmaaldrich.cn |
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shlmai
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www.shlmai.net/ |
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