| Identification | Back Directory | [Name]
dutomycin | [CAS]
146663-67-4 | [Synonyms]
dutomycin
1,4,6,7(6aH,10H)-Naphthacenetetrone, 8-acetyl-10-[[5-[[2,6-dideoxy-4-O-(2,4-dimethyl-1-oxo-2-heptenyl)-3-C-methyl-α-L-xylo-hexopyranosyl]oxy]tetrahydro-6-methyl-2H-pyran-2-yl]oxy]-10a,11-dihydro-5,6a,9,10a-tetrahydroxy-2-methoxy-12-methyl-, [2S-[2α(6aR*,10S*,10aS*),5β(2Z,4S*),6α]]- (9CI) | [Molecular Formula]
C44H54O17 | [MOL File]
146663-67-4.mol | [Molecular Weight]
854.89 |
| Hazard Information | Back Directory | [Uses]
Dutomycin is a SERPINB6 inhibitor with a binding constant (KD) of 1.236 μM. Dutomycin can induce autophagy and apoptosis in cancer cells and inhibit the growth of cancer cells in a zebrafish xenograft model. Dutomycin is promising for research of cancers[1]. | [Definition]
ChEBI: Dutomycin is an anthracycline antibiotic of formula C44H54O17 isolated from Streptomyces species. It directly binds to the human serine protease inhibitor B6 (SERPINB6), inducing autophagy and apoptosis. It has a role as a bacterial metabolite, an autophagy inducer, an apoptosis inducer and an antineoplastic agent. It is an anthracycline antibiotic, a tertiary alpha-hydroxy ketone, a member of phenols, an ether, a member of 1,4-benzoquinones, a disaccharide derivative, an enol, an enoate ester, a carbopolycyclic compound and a carbohydrate-containing antibiotic. | [References]
[1] Jang M, et al. Dutomycin Induces Autophagy and Apoptosis by Targeting the Serine Protease Inhibitor SERPINB6. ACS Chem Biol. 2021 Feb 19;16(2):360-370. DOI:10.1021/acschembio.0c00889 |
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