| Identification | Back Directory | [Name]
N-(5-(3-(7-(3-fluorophenyl)-3H-imidazo[4,5-c]pyridin-2-yl)-1H-indazol-5-yl)pyridin-3-yl)-3-methylbutanamide | [CAS]
1467093-03-3 | [Synonyms]
CPD1633
SM04690
SM-04690;SM 04690;SM04690
N-(5-(3-(7-(3-fluorophenyl)-3H-imidazo[4,5-c]pyridin-2-yl)-1H-indazol-5-yl)pyridin-3-yl)-3-methylbutanamide
Butanamide, N-[5-[3-[7-(3-fluorophenyl)-3H-imidazo[4,5-c]pyridin-2-yl]-1H-indazol-5-yl]-3-pyridinyl]-3-methyl- | [Molecular Formula]
C29H24FN7O | [MDL Number]
MFCD30489411 | [MOL File]
1467093-03-3.mol | [Molecular Weight]
505.55 |
| Chemical Properties | Back Directory | [density ]
1.365±0.06 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,2-8°C | [solubility ]
DMSO:27.5(Max Conc. mg/mL);54.4(Max Conc. mM) | [form ]
Solid | [pka]
7.75±0.40(Predicted) | [color ]
Light yellow to gray | [InChIKey]
AQDWDWAYVBQMAM-UHFFFAOYSA-N | [SMILES]
C(NC1=CC(C2C=CC3=C(C=2)C(C2=NC4C(C5=CC=CC(F)=C5)=CN=CC=4N2)=NN3)=CN=C1)(=O)CC(C)C |
| Hazard Information | Back Directory | [Uses]
Adavivint is an intra-articular potential disease-modifying osteoarthritis drug. | [Biological Activity]
Adavivint (SM04690) is a potent canonical Wnt signaling pathway inhibitor with EC50 of 19.5 nM for TCF/LEF reporter gene. It was more potent than other known Wnt inhibitors in multiple cellular experiments. | [in vitro]
Treatment of bone marrow-derived human mesenchymal stem cells (CD29+, CD44+ CD166+ CD105+ CD45-) with SM04690 induced a concentration-dependent decrease in Wnt pathway gene expression (ASCL1, LEF1, TCF7L2, TCF7 , C-262 MYC and AXIN2). Selective activation of Wnt signaling pathway with Wnt3a or GSK3β inhibitor CHIR-99021, in IEC6 (intestinal stem cells sensitive to Wnt activation), M04690 can inhibit the expression of AXIN2 and LGR5; in hMSCs, inhibit the expression of AXIN2, TCF7 and LEF1 Express. It has minimal effects on non-canonical Wnt signaling and BMP signaling. In vitro, SM04690 protects chondrocytes from metabolic breakdown. | [in vivo]
Intra-articular injection of Adavivint promotes cartilage growth and improves joint health in a rat model of knee osteoarthritis. In vivo, it reduces cartilage breakdown. | [target]
| Target | Value | Wnt
() | [storage]
Store at -20°C |
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Tags:1467093-03-3
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