ChemicalBook--->CAS DataBase List--->152362-51-1

152362-51-1

152362-51-1 Structure

152362-51-1 Structure
IdentificationBack Directory
[Name]

EMA400
[CAS]

152362-51-1
[Synonyms]

EMA400
EMA400; EMA 400; EMA-400; PD-126055; PD126055; PD 126055;152362-51-1
3-Isoquinolinecarboxylic acid, 2-(2,2-diphenylacetyl)-1,2,3,4-tetrahydro-6-methoxy-5-(phenylmethoxy)-
[Molecular Formula]

C32H29NO5
[MOL File]

152362-51-1.mol
[Molecular Weight]

507.58
Chemical PropertiesBack Directory
[Boiling point ]

745.3±60.0 °C(Predicted)
[density ]

1.256±0.06 g/cm3(Predicted)
[pka]

3.54±0.20(Predicted)
Hazard InformationBack Directory
[Uses]

rac-Olodanrigan (rac-EMA401; EMA400) is a racemic mixture of the S-enantiomer (EMA401; HY-13106) and R-enantiomer (EMA402). rac-Olodanrigan is a potent and selective AT2 receptor antagonist with IC50s of 75.2 nM and 2918 nM for AT2R and AT1R, respectively. rac-Olodanrigan evokes dose-dependent relief of mechanical allodynia in the ipsilateral hind paws of rats with a chronic constriction injury (CCI) of the sciatic nerve[1].
[IC 50]

AT2 Receptor: 75.2 nM (IC50); AT1 Receptor: 2918 nM (IC50)
[References]

[1] Maree T Smith. Nonopioid analgesics discovery and the Valley of Death: EMA401 from concept to clinical trial. Pain. 2022 Nov 1;163(Suppl 1):S15-S28. DOI:10.1097/j.pain.0000000000002675
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