| Identification | Back Directory | [Name]
TRECOVIRSEN | [CAS]
153021-75-1 | [Synonyms]
D(p-Thio)(C-T-C-T-C-G-C-A-C-C-C-A-T-C-T-C-T-C-T-C-C-T-T-C-T)-dna
Dna, D(p-thio)(C-T-C-T-C-G-C-A-C-C-C-A-T-C-T-C-T-C-T-C-C-T-T-C-T)-
Deoxyribonucleic acid, D(p-thio)(C-T-C-T-C-G-C-A-C-C-C-A-T-C-T-C-T-C-T-C-C-T-T-C-T)- | [Molecular Formula]
C237H310N72O131P24S24 | [MDL Number]
MFCD01941407 | [MOL File]
153021-75-1.mol | [Molecular Weight]
7776.33 |
| Hazard Information | Back Directory | [Uses]
Trecovirsen (GEM91) is a 25-mer antisense phosphorothioate oligonucleotide targeted at the gag site of the HIV gene. | [References]
[1] Séréni D, Tubiana R, Lascoux C, et al. Pharmacokinetics and tolerability of intravenous trecovirsen (GEM 91), an antisense phosphorothioate oligonucleotide, in HIV-positive subjects. J Clin Pharmacol. 1999;39(1):47-54. DOI:10.1177/00912709922007552
[2] Pedziwiatr-Werbicka E, Fuentes E, Dzmitruk V, et al. Novel 'Si-C' carbosilane dendrimers as carriers for anti-HIV nucleic acids: studies on complexation and interaction with blood cells. Colloids Surf B Biointerfaces. 2013;109:183-189. DOI:10.1016/j.colsurfb.2013.03.045 |
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