| Identification | Back Directory | [Name]
TYRPHOSTIN AG 1112 | [CAS]
153150-84-6 | [Synonyms]
Tyrphostin AG 1112 >=98%, solid
1H-Pyrazole-3-acetonitrile, 5-amino-4-cyano-α-(1H-indol-3-ylmethylene)-, (αZ)-
1H-Pyrazole-3-acetonitrile, 5-amino-4-cyano-alpha-(1H-indol-3-ylmethyl ene), (Z)- | [Molecular Formula]
C15H10N6 | [MDL Number]
MFCD01868804 | [MOL File]
153150-84-6.mol | [Molecular Weight]
274.28 |
| Hazard Information | Back Directory | [Uses]
Tyrphostin AG1112 is a potent inhibitors of CK II. Tyrphostin AG1112 inhibits p210bcr-abl tyrosine kinase, with IC50 values of 2, 15, 20 μM in p210bcr-abl, EGFR and PDGFR cells, respectively[1][2]. | [References]
[1] T B Kang, et al. Action of 3 tyrphostin derivatives on casein kinase II from rat liver. Zhongguo Yao Li Xue Bao. 1997 Jan;18(1):56-8. PMID:10072895
[2] M Anafi, et al. Tyrphostin-induced inhibition of p210bcr-abl tyrosine kinase activity induces K562 to differentiate. Blood. 1993 Dec 15;82(12):3524-9. PMID:7505115 |
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