| Identification | Back Directory | [Name]
amyloid beta-protein (17-42) | [CAS]
155178-13-5 | [Synonyms]
amyloid beta-protein (17-42)
L-Alanine, L-leucyl-L-valyl-L-phenylalanyl-L-phenylalanyl-L-alanyl-L-α-glutamyl-L-α-aspartyl-L-valylglycyl-L-seryl-L-asparaginyl-L-lysylglycyl-L-alanyl-L-isoleucyl-L-isoleucylglycyl-L-leucyl-L-methionyl-L-valylglycylglycyl-L-valyl-L-valyl-L-isoleucyl- | [Molecular Formula]
C119H194N28O33S | [MOL File]
155178-13-5.mol | [Molecular Weight]
2577.08 |
| Hazard Information | Back Directory | [Uses]
Amyloid 17-42 (Aβ(17-42)) is a major constituent of diffuse plaques in Alzheimer's disease and cerebellar pre-amyloid in Down's syndrome, derived by alpha- and gamma-secretase cleavage of the amyloid precursor protein (APP). Amyloid 17-42 can induce neuronal apoptosis via a Fas-like/caspase-8 activation pathway[1]. | [References]
[1] Wanli Wei, et al. Abeta 17-42 in Alzheimer's disease activates JNK and caspase-8 leading to neuronal apoptosis. Brain. 2002 Sep;125(Pt 9):2036-43. DOI:10.1093/brain/awf205 |
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