| Identification | Back Directory | [Name]
2-(4-((7-CHLORO-2-QUINOXALINYL)OXY)-PHENOXY)-PROPIONIC ACID | [CAS]
157435-10-4 | [Synonyms]
XK469
NSC 697887
2-[4-[(7-chloro-2-quinoxalinyl)oxy]phenoxy]Propanoic acid
2-(4-((7-CHLORO-2-QUINOXALINYL)OXY)-PHENOXY)-PROPIONIC ACID
Propanoic acid, 2-[4-[(7-chloro-2-quinoxalinyl)oxy]-phenoxy]-, (+/-)-
2-(4-((7-Chloro-2-quinoxalinyl)oxy)phenoxy)propionic acid, NSC 697887 | [Molecular Formula]
C17H13ClN2O4 | [MDL Number]
MFCD05861262 | [MOL File]
157435-10-4.mol | [Molecular Weight]
344.75 |
| Chemical Properties | Back Directory | [Boiling point ]
533.3±50.0 °C(Predicted) | [density ]
1.409±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C | [form ]
solid | [pka]
3.11±0.10(Predicted) | [InChI]
1S/C17H13ClN2O4/c1-10(17(21)22)23-12-3-5-13(6-4-12)24-16-9-19-14-7-2-11(18)8-15(14)20-16/h2-10H,1H3,(H,21,22) | [InChIKey]
NUQZXROIVGBRGR-UHFFFAOYSA-N | [SMILES]
CC(Oc1ccc(Oc2cnc3ccc(Cl)cc3n2)cc1)C(O)=O |
| Hazard Information | Back Directory | [Uses]
XK469 is an analog of the herbicide assure. XK469 downregulation growth arrest-specific 2 (GAS2) gene expression. XK469 has antitumor activity[1]. | [Biological Activity]
XK469 is a topoisomerase IIβ inhibitor; apoptosis inducer. | [References]
[1] Chi-Jung Huang, et al. Upregulation of the growth arrest-specific-2 in recurrent colorectal cancers, and its susceptibility to chemotherapy in a model cell system. Biochim Biophys Acta. 2016, 1862, 7. DOI:10.1016/j.bbadis.2016.04.010 |
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