| Chemical Properties | Back Directory | [Boiling point ]
687.6±55.0 °C(Predicted) | [density ]
1.32±0.1 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO: 50mg/mL | [form ]
powder | [pka]
13.48±0.40(Predicted) | [color ]
pale yellow |
| Hazard Information | Back Directory | [Description]
PF-05387252 is a potent and selective IRAK4 inhibitor. | [Uses]
PF-05387252 is a potent and selective IRAK4 inhibitor with the activity of inhibiting endogenous TLR signaling pathways. PF-05387252 has shown anti-inflammatory activity in experimental models and may have potential clinical application value in inhibiting psoriasis. Although PF-05387252 and its related compounds have shown anti-inflammatory effects in animal models, their efficacy in inhibiting psoriasis has not yet been verified[1]. | [References]
[1] Natural Modulators of Endosomal Toll-Like Receptor-Mediated Psoriatic Skin Inflammation DOI:10.1155/2017/7807313 |
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| Company Name: |
Merck KGaA
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| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
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