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1627900-92-8

1627900-92-8 Structure

1627900-92-8 Structure
IdentificationBack Directory
[Name]

Methanone, [2-chloro-3-(trifluoromethyl)phenyl][1,4,6,7-tetrahydro-1-(2-pyrimidinyl)-5H-1,2,3-triazolo[4,5-c]pyridin-5-yl]-
[CAS]

1627900-92-8
[Synonyms]

P2X7 receptor antagonist-3
Methanone, [2-chloro-3-(trifluoromethyl)phenyl][1,4,6,7-tetrahydro-1-(2-pyrimidinyl)-5H-1,2,3-triazolo[4,5-c]pyridin-5-yl]-
[Molecular Formula]

C17H12ClF3N6O
[MOL File]

1627900-92-8.mol
[Molecular Weight]

408.77
Chemical PropertiesBack Directory
[Boiling point ]

639.5±65.0 °C(Predicted)
[density ]

1.61±0.1 g/cm3(Predicted)
[pka]

-1.49±0.20(Predicted)
Hazard InformationBack Directory
[Uses]

P2X7 receptor antagonist-3 is a potent P2X7 receptor antagonist with P2X7R IC50 values of 4.2 nM in humans and 6.8 nM in rats[1].
[IC 50]

hP2X7R: 4.2 nM (IC50); rP2X7R: 6.8 nM (IC50)
[References]

[1] Brad M Savall, et al. Synthesis, SAR, and Pharmacological Characterization of Brain Penetrant P2X7 Receptor Antagonists. ACS Med Chem Lett. 2015 Apr 24;6(6):671-6. DOI:10.1021/acsmedchemlett.5b00089
1627900-92-8 suppliers list
Company Name: TargetMol Chemicals Inc.
Tel: +17819995354 , +17819995354
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Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
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