| Identification | Back Directory | [Name]
GS-626510 | [CAS]
1637770-13-8 | [Synonyms]
GS-626510
Quinoline, 5-[2-cyclopropyl-5-(3,5-dimethyl-4-isoxazolyl)-1H-benzimidazol-7-yl]-6-methyl- | [Molecular Formula]
C25H22N4O | [MDL Number]
MFCD31813770 | [MOL File]
1637770-13-8.mol | [Molecular Weight]
394.47 |
| Hazard Information | Back Directory | [Description]
GS-626510 is a potent BET family bromodomains inhibitor. It acts by targeting BRD2/3/4, and BRDT. | [Uses]
GS-626510 is a potent, and orally active BET family bromodomains inhibitor, with Kd values of 0.59-3.2 nM for BRD2/3/4, with IC50 values of 83 nM and 78 nM foe BD1 and BD2, respectively[1]. | [IC 50]
BRD2: 0.59-2.5 nM (Kd); BRD3: 0.65-0.66 nM (Kd); BRD4: 1.3-3.2 nM (Kd); BD1: 83 nM (IC50); BD2: 78 nM (IC50) | [References]
[1] Sperandio D, et al. Structure-guided discovery of a novel, potent, and orally bioavailable 3,5-dimethylisoxazole aryl-benzimidazole BET bromodomain inhibitor. Bioorg Med Chem. 2019 Feb 1;27(3):457-469. DOI:10.1016/j.bmc.2018.11.020 |
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| Company Name: |
cjbscvictory
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| Tel: |
13348960310 13348960310 |
| Website: |
www.weikeqi-biotech.com/ |
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