| Identification | Back Directory | [Name]
2-Pyrazinecarboxamide, 5-[(3R)-3-(3-methyl-2-oxo-1-imidazolidinyl)-1-piperidinyl]-3-[[4-(4-piperidinyl)phenyl]amino]- | [CAS]
1791402-91-9 | [Synonyms]
(R)-5-[3-(3-Methyl-2-oxo-1-imidazolidinyl)-1-piperidyl]-3-[[4-(4-piperidyl)phenyl]amino]pyrazine-2-carboxamide
(R)-5-(3-(3-Methyl-2-oxoimidazolidin-1-yl)piperidin-1-yl)-3-((4-(piperidin-4-yl)phenyl)amino)pyrazine-2-carboxamide
2-Pyrazinecarboxamide, 5-[(3R)-3-(3-methyl-2-oxo-1-imidazolidinyl)-1-piperidinyl]-3-[[4-(4-piperidinyl)phenyl]amino]- | [Molecular Formula]
C25H34N8O2 | [MOL File]
1791402-91-9.mol | [Molecular Weight]
478.59 |
| Hazard Information | Back Directory | [Uses]
BTK ligand 12 is a PROTAC target protein ligand (Ligands for Target Protein for PROTACs). BTK ligand 12 can serve as an active control for the target protein ligand of NRX-0492 (HY-153357)[1]. | [References]
[1] Zhang D, et al. NRX-0492 degrades wild-type and C481 mutant BTK and demonstrates in vivo activity in CLL patient-derived xenografts. Blood. 2023 Mar 30;141(13):1584-1596. DOI:10.1182/blood.2022016934 |
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