ChemicalBook--->CAS DataBase List--->1801896-05-8

1801896-05-8

1801896-05-8 Structure

1801896-05-8 Structure
IdentificationBack Directory
[Name]

EBI-1051 (EBI1051)
[CAS]

1801896-05-8
[Synonyms]

EBI-1051
EBI-1051 (EBI1051)
[Molecular Formula]

C18H15F2IN2O5
[MDL Number]

MFCD31813631
[MOL File]

1801896-05-8.mol
[Molecular Weight]

504.22
Chemical PropertiesBack Directory
[density ]

1.813±0.06 g/cm3(Predicted)
[pka]

13.76±0.10(Predicted)
Hazard InformationBack Directory
[Description]

EBI-1051 is a potent, and selective inhibitor of MEK1.
[Uses]

EBI-1051 is a highly potent and orally efficacious MEK inhibitor with an IC50 of 3.9 nM.
[References]

[1] Lu B, et al. Discovery of EBI-1051: A novel and orally efficacious MEK inhibitor with benzofuran scaffold. Bioorg Med Chem. 2018 Feb 1;26(3):581-589. DOI:10.1016/j.bmc.2017.12.019
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