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1807518-72-4

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  1. 1807518-72-4 Structure

    1807518-72-4 Structure
    IdentificationBack Directory
    [Name]

    Mal-PEG1-NHS ester
    [CAS]

    1807518-72-4
    [Synonyms]

    Mal-PEG1-SPA
    CAS_1807518-72-4
    Mal-PEG1-NHS ester
    2,5-Dioxopyrrolidin-1-yl 3-(2-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)ethoxy)propanoate
    Propanoic acid, 3-[2-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)ethoxy]-, 2,5-dioxo-1-pyrrolidinyl ester
    [Molecular Formula]

    C13H14N2O7
    [MDL Number]

    MFCD26127783
    [MOL File]

    1807518-72-4.mol
    [Molecular Weight]

    310.26
    Chemical PropertiesBack Directory
    [Boiling point ]

    488.4±55.0 °C(Predicted)
    [density ]

    1.48±0.1 g/cm3(Predicted)
    [solubility ]

    Soluble in DCM
    [form ]

    Solid
    [pka]

    -2.35±0.20(Predicted)
    [color ]

    White to off-white
    [InChI]

    InChI=1S/C13H14N2O7/c16-9-1-2-10(17)14(9)6-8-21-7-5-13(20)22-15-11(18)3-4-12(15)19/h1-2H,3-8H2
    [InChIKey]

    AMRJPIJPLBUEHO-UHFFFAOYSA-N
    [SMILES]

    C(ON1C(=O)CCC1=O)(=O)CCOCCN1C(=O)C=CC1=O
    Hazard InformationBack Directory
    [Description]

    Mal-PEG1-NHS ester is a PEG linker containing a maleimide group and an NHS ester group. The hydrophilic PEG spacer increases solubility in aqueous media. The NHS ester can be used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules. The maleimide group will react with a thiol group to form a covalent bond, enabling the connection of biomolecule with a thiol.
    [Biological Activity]

    Mal-PEG1-NHS ester is a cleavable PEG-based ADC linker for the synthesis of antibody drug conjugates (ADCs). It is a PEG-based PROTAC linker that can be used to synthesize PROTACs.
    [in vitro]

    ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

    [target]

    Cleavable

    PEGs

    Spectrum DetailBack Directory
    [Spectrum Detail]

    Mal-PEG1-NHS ester(1807518-72-4)1HNMR
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