| Identification | Back Directory | [Name]
2-Pyrazinecarboxamide, N-[3-[(4R,5R,6R)-2-amino-5-fluoro-5,6-dihydro-4,6-dimethyl-4H-1,3-thiazin-4-yl]-4-fluorophenyl]-5-(fluoromethoxy)- | [CAS]
1818239-19-8 | [Synonyms]
β-Secretase Inhibitor I
2-Pyrazinecarboxamide, N-[3-[(4R,5R,6R)-2-amino-5-fluoro-5,6-dihydro-4,6-dimethyl-4H-1,3-thiazin-4-yl]-4-fluorophenyl]-5-(fluoromethoxy)- | [Molecular Formula]
C18H18F3N5O2S | [MOL File]
1818239-19-8.mol | [Molecular Weight]
425.43 |
| Hazard Information | Back Directory | [Uses]
β-Secretase Inhibitor I is an extremely potent β-secretase inhibitor with reduced cardiovascular and liver toxicity. | [References]
[1] Tadano G, et al. Discovery of an Extremely Potent Thiazine-Based β-Secretase Inhibitor with Reduced Cardiovascular and Liver Toxicity at a Low Projected Human Dose. J Med Chem. 2019 Oct 24;62(20):9331-9337. DOI:10.1021/acs.jmedchem.9b01140 |
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