ChemicalBook--->CAS DataBase List--->1840886-10-3

1840886-10-3

    1840886-10-3 Structure

    1840886-10-3 Structure
    IdentificationBack Directory
    [Name]

    DBCO-PEG4-amine
    [CAS]

    1840886-10-3
    [Synonyms]

    DBCO-PEG2-amine TFA salt
    DBCO-PEG4-amine TFA salt
    Dibenz[b,f]azocine-5(6H)-butanamide, N-(14-amino-3,6,9,12-tetraoxatetradec-1-yl)-11,12-didehydro-γ-oxo-
    [Molecular Formula]

    C29H37N3O6
    [MOL File]

    1840886-10-3.mol
    [Molecular Weight]

    523.63
    Chemical PropertiesBack Directory
    [Boiling point ]

    784.1±60.0 °C(Predicted)
    [density ]

    1.23±0.1 g/cm3(Predicted)
    [solubility ]

    Soluble in DMSO, DCM, DMF
    [form ]

    Viscous Liquid
    [pka]

    15.14±0.46(Predicted)
    [color ]

    Light yellow to yellow
    [InChIKey]

    NFJQULPXXATMFO-UHFFFAOYSA-N
    [SMILES]

    C(N1CC2=CC=CC=C2C#CC2=CC=CC=C12)(=O)CCC(=O)NCCOCCOCCOCCOCCN
    Hazard InformationBack Directory
    [Description]

    DBCO-PEG4-amine is a PEG linker which contains DBCO and amine moieties. The DBCO group is commonly used in copper-free Click Chemistry reactions. The amine group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The hydrophilic PEG spacer increases the water solubility of the compound.
    [Biological Activity]

    DBCO-PEG4-amine is a PROTAC bridge and belongs to the PEG class. DBCO-PEG4-amine can be used to synthesize a series of PROTAC molecules. It is a cleavable ADC linker for the synthesis of antibody drug conjugates (ADCs).
    [in vitro]

    PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
    ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

    [target]

    Cleavable

    PEGs

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