| Identification | Back Directory | [Name]
DBCO-PEG4-amine | [CAS]
1840886-10-3 | [Synonyms]
DBCO-PEG2-amine TFA salt DBCO-PEG4-amine TFA salt Dibenz[b,f]azocine-5(6H)-butanamide, N-(14-amino-3,6,9,12-tetraoxatetradec-1-yl)-11,12-didehydro-γ-oxo- | [Molecular Formula]
C29H37N3O6 | [MOL File]
1840886-10-3.mol | [Molecular Weight]
523.63 |
| Chemical Properties | Back Directory | [Boiling point ]
784.1±60.0 °C(Predicted) | [density ]
1.23±0.1 g/cm3(Predicted) | [solubility ]
Soluble in DMSO, DCM, DMF | [form ]
Viscous Liquid | [pka]
15.14±0.46(Predicted) | [color ]
Light yellow to yellow | [InChIKey]
NFJQULPXXATMFO-UHFFFAOYSA-N | [SMILES]
C(N1CC2=CC=CC=C2C#CC2=CC=CC=C12)(=O)CCC(=O)NCCOCCOCCOCCOCCN |
| Hazard Information | Back Directory | [Description]
DBCO-PEG4-amine is a PEG linker which contains DBCO and amine moieties. The DBCO group is commonly used in copper-free Click Chemistry reactions. The amine group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The hydrophilic PEG spacer increases the water solubility of the compound. | [Biological Activity]
DBCO-PEG4-amine is a PROTAC bridge and belongs to the PEG class. DBCO-PEG4-amine can be used to synthesize a series of PROTAC molecules. It is a cleavable ADC linker for the synthesis of antibody drug conjugates (ADCs). | [in vitro]
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker. | [target]
|
|
|
Tags:1840886-10-3
Related Product Information
|
|
1537170-85-6
1255942-07-4
2226472-28-0
1480516-75-3
2182601-68-7
1427004-19-0
2364591-79-5
2828433-65-2
2249926-63-2
1353016-71-3
2377004-08-3
2228857-34-7
1393350-27-0
2754384-59-1
1418217-95-4
2247993-79-7
2375193-74-9
2093409-57-3
|
屯门区|
榕江县|
昭平县|
花莲市|
延边|
平武县|
独山县|
株洲市|
柳林县|
黄骅市|
溆浦县|
伽师县|
泰兴市|
固镇县|
扶绥县|
惠州市|
桂东县|
鄢陵县|
麻城市|
鲁山县|
青阳县|
廉江市|
东至县|
天台县|
呼伦贝尔市|
塔河县|
阜城县|
毕节市|
浙江省|
乃东县|
东莞市|
南陵县|
拉萨市|
杭锦后旗|
驻马店市|
绥阳县|
共和县|
黄浦区|
江永县|
巴中市|
崇礼县|
|