| Hazard Information | Back Directory | [Description]
DH376 is a highly potent , in vivo active compound that inhibits DAGLα in a time- and dose dependent manner in mouse brain. DH376 showed picomolar activity | [Uses]
DH-376 is a potent diacylglycerol lipase inhibitor with pIC50 values of 8.6 and 8.9 for ABHD6 and DAGLα, respectively. DH-376 prevents fasting-induced refeeding of mice[1]. DH-376 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | [in vivo]
DH-376 (50 mg/kg; i.p.) reduces fasting-induced refeeding of mice[1]. | Animal Model: | male C57Bl/6J mice[1] | | Dosage: | 50 mg/kg | | Administration: | intraperitoneal injection | | Result: | Inhibitd fasting-induced refeeding. |
| [References]
[1] Deng H, et, al. Triazole Ureas Act as Diacylglycerol Lipase Inhibitors and Prevent Fasting-Induced Refeeding. J Med Chem. 2017 Jan 12;60(1):428-440. DOI:10.1021/acs.jmedchem.6b01482 |
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