| Identification | Back Directory | [Name]
Hydroxychloroquine Sulfate EP Impurity C-d4 (Desethyl Hydroxy Chloroquine-d4) | [CAS]
1854126-47-8 | [Synonyms]
HydroxychloroquineSulfateEPImpurityC-d4
Hydroxychloroquine Sulfate EP Impurity C-d4 (Desethyl Hydroxy Chloroquine-d4) | [Molecular Formula]
C16H22ClN3O | [MOL File]
1854126-47-8.mol | [Molecular Weight]
307.82 |
| Hazard Information | Back Directory | [Uses]
Cletoquine-d4 is deuterium labeled Cletoquine. Cletoquine (Desethylhydroxychloroquine) is a major active metabolite of Hydroxychloroquine. Cletoquine is produced in the liver by CYP2D6, CYP3A4, CYP3A5, and CYP2C8 isoenzymes. Cletoquine is also a Chloroquine derivative and has the ability to against the chikungunya virus (CHIKV). Cletoquine has antimalarial effects and has the potential for autoimmune diseases treatment[1][2]. | [Biological Activity]
Desethyl hydroxychloroquine-d4 is intended for use as an internal standard for the quantification of desethyl hydroxychloroquine by GC- or LC-MS. Desethyl hydroxychloroquine is an active metabolite of hydroxychloroquine .1 It is formed via the desethylation of hydroxychloroquine in the liver, a process mediated by the cytochrome P450 (CYP) isoforms CYP2D6, CYP3A4, CYP3A5, and CYP2C8. | [IC 50]
Plasmodium | [storage]
Store at -20°C | [References]
1.Charlier, B., Pingeon, M., Dal Piaz, F., et al.Development of a novel ion-pairing HPLC-FL method for the separation and quantification of hydroxychloroquine and its metabolites in whole bloodBiomed. Chromatogr.32(8)e4258(2018)
|
|
| Company Name: |
ChemeGen
|
| Tel: |
13060007561 |
| Website: |
https://www.chemegen.com |
|