| Identification | Back Directory | [Name]
CP 339818 HYDROCHLORIDE | [CAS]
185855-91-8 | [Synonyms]
CP339818HCl
CP 339818 hydrochlor
CP 339818 HYDROCHLORIDE
(1-Benzyl-1H-quinolin-4-ylidene)-pentyl-amine
1-Pentanamine, N-[1-(phenylmethyl)-4(1H)-quinolinylidene]-
N-[1-(PhenylMethyl)-4(1H)-quinolinylidene]-1 pentanaMine HCl
N-(1-Benzylquinolin-4(1H)-ylidene)pentan-1-aMine hydrochloride
N-[1-(phenylMethyl)-4(1H)-quinolinylidene]-1 pentanaMine hydroch
(5Z)-N-(1-benzylquinolin-4(1H)-ylidene)pentan-1-amine hydrochloride
N-[1-(PHENYLMETHYL)-4(1H)-QUINOLINYLIDENE]-1 PENTANAMINE HYDROCHLORIDE | [Molecular Formula]
C21H24N2 | [MDL Number]
MFCD03098565 | [MOL File]
185855-91-8.mol | [Molecular Weight]
304.43 |
| Hazard Information | Back Directory | [Uses]
CP-339818 is a non-peptide drug with potent Kv1.3 channel blocking activity. CP-339818 is able to effectively inhibit the activation of human T cells. By selectively blocking Kv1.3, CP-339818 is of great value in immune system research. The drug inhibits the C-type inactivated state of Kv1.3 channels in a use-dependent manner. CP-339818 has significantly weaker blocking effects on Kv1.1, Kv1.2, Kv1.5, Kv1.6, Kv3.1-4, and Kv4.2 channels, and only shows some inhibition on the Kv1.4 channel[1]. | [Biological Activity]
Potent, non-peptide K V 1.3 channel antagonist that preferentially binds to the C-type inactivated state of the channel (IC 50 ~ 200 nM) . Inhibits K V 1.4 with an IC 50 of ~ 300 nM. Selective over K V 1.1, K V 1.2, K V 1.5, K V 1.6, K V 3.1-4, and K V 4.2. | [References]
[1] Novel nonpeptide agents potently block the C-type inactivated conformation of Kv1.3 and suppress T cell activation PMID:8967992 |
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| Company Name: |
SynAsst Chemical.
|
| Tel: |
021-60343070 |
| Website: |
www.hezefdc.com/ShowSupplierProductsList15848/0_EN.htm |
| Company Name: |
Alomone Labs
|
| Tel: |
4008-168-068 13121892008 |
| Website: |
www.alomone.com |
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