| Identification | Back Directory | [Name]
Pentanoic acid, 5-[[2-(acetylamino)-3,4,6-tri-O-benzoyl-2-deoxy-β-D-galactopyranosyl]oxy]- | [CAS]
186613-57-0 | [Synonyms]
TriGalNAc CBz
5-[(3,4,6-Tri-O-benzoyl-2-acetylamido-2-deoxy-β-D-galactopyranosyl)oxy]-pentanoic Acid
Pentanoic acid, 5-[[2-(acetylamino)-3,4,6-tri-O-benzoyl-2-deoxy-β-D-galactopyranosyl]oxy]- | [Molecular Formula]
C34H35NO11 | [MOL File]
186613-57-0.mol | [Molecular Weight]
633.65 |
| Chemical Properties | Back Directory | [Boiling point ]
819.6±65.0 °C(Predicted) | [density ]
1.34±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
4.68±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
TriGalNAc CBz is a GalNAc derivative and tri-GalNAc is an asialoglycoprotein receptor (ASGPR) ligand. TriGalNAc CBz can be used for mRNA drug delivery as well as lysosomal targeted chimerism (LYTAC) studies[1]. | [References]
[1] Kallanthottathil G. Rajeev, et al. Compositions and methods for targeted rna delivery. WO2021178725.
[2] Biessen EA, Sliedregt-Bol K, 'T Hoen PA, et al. Design of a targeted peptide nucleic acid prodrug to inhibit hepatic human microsomal triglyceride transfer protein expression in hepatocytes. Bioconjug Chem. 2002;13(2):295-302. DOI:10.1021/bc015550g
[3] Ahn G, et al. LYTACs that engage the asialoglycoprotein receptor for targeted protein degradation[J]. Nature Chemical Biology, 2021, 17(9): 937-946. |
|
|