| Identification | Back Directory | [Name]
Spiro[5,7-etheno-1H,11H-cyclobut[i][1,4]oxazepino[3,4-f][1,2,7]thiadiazacyclohexadecine-2(3H),1'(2'H)-naphthalen]-8(9H)-one, 6'-chloro-3',4',12,13,16,16a,17,18,18a,19-decahydro-16-hydroxy-11,12-dimethyl-, 10,10-dioxide, (1'S,11R,12S,14E,16S,16aR,18aR)- | [CAS]
1883727-31-8 | [Synonyms]
Mcl-1 inhibitor 9
Spiro[5,7-etheno-1H,11H-cyclobut[i][1,4]oxazepino[3,4-f][1,2,7]thiadiazacyclohexadecine-2(3H),1'(2'H)-naphthalen]-8(9H)-one, 6'-chloro-3',4',12,13,16,16a,17,18,18a,19-decahydro-16-hydroxy-11,12-dimethyl-, 10,10-dioxide, (1'S,11R,12S,14E,16S,16aR,18aR)- | [Molecular Formula]
C32H39ClN2O5S | [MOL File]
1883727-31-8.mol | [Molecular Weight]
599.18 |
| Hazard Information | Back Directory | [Uses]
Mcl-1 inhibitor 9 (example 2) is a myeloid cell leukemia 1 (Mcl-1) inhibitor with IC50 value of 0.21889 nM. Mcl-1 inhibitor 9 shows anti-tumor activity[1]. | [References]
[1] Sean P. Brown, et al. Tetrahydronaphthalene derivatives that inhibit mcl-1 protein. WO2016033486A1. |
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