| Identification | Back Directory | [Name]
6-[amino-(4-chlorophenyl)-(3-methylimidazol-4-yl)methyl]-4-(3-chloroph enyl)-1-methyl-quinolin-2-one | [CAS]
192185-68-5 | [Synonyms]
6-[amino-(4-chlorophenyl)-(3-methylimidazol-4-yl)methyl]-4-(3-chloroph enyl)-1-methyl-quinolin-2-one | [Molecular Formula]
C27H22Cl2N4O | [MDL Number]
MFCD20526332 | [MOL File]
192185-68-5.mol | [Molecular Weight]
489.4 |
| Chemical Properties | Back Directory | [Melting point ]
214 °C(Solv: acetonitrile (75-05-8); dichloromethane (75-09-2); methanol (67-56-1)) | [Boiling point ]
681.7±55.0 °C(Predicted) | [density ]
1.33±0.1 g/cm3(Predicted) | [pka]
7.20±0.10(Predicted) |
| Hazard Information | Back Directory | [Description]
R 115777 is a farnesyl transferase inhibitor. | [Uses]
(Rac)-Tipifarnib ((Rac)-IND 58359; (Rac)-R115777) is a potent farnesyl protein transferase inhibitor that specifically targets the pro-tailation process of Ras proteins. (Rac)-Tipifarnib showed significant in vivo antitumor effects after oral administration to mice[1]. | [References]
[1] Venet M, et al. Farnesyl protein transferase inhibitor ZARNESTRA? R115777-History of a discovery[J]. Current Topics in Medicinal Chemistry, 2003, 3(10): 1095-1102. |
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