| Identification | Back Directory | [Name]
5H-Pyrazolo[4,3-c]pyridine-5-carboxylic acid, 3-[7-(difluoromethyl)-3,4-dihydro-6-(1-methyl-1H-pyrazol-4-yl)-1(2H)-quinolinyl]-1,4,6,7-tetrahydro-1-(4-piperidinyl)-, 1,1-dimethylethyl ester | [CAS]
1936431-36-5 | [Synonyms]
Piperidine-GNE-049-N-Boc
5H-Pyrazolo[4,3-c]pyridine-5-carboxylic acid, 3-[7-(difluoromethyl)-3,4-dihydro-6-(1-methyl-1H-pyrazol-4-yl)-1(2H)-quinolinyl]-1,4,6,7-tetrahydro-1-(4-piperidinyl)-, 1,1-dimethylethyl ester | [Molecular Formula]
C30H39F2N7O2 | [MOL File]
1936431-36-5.mol | [Molecular Weight]
567.67 |
| Chemical Properties | Back Directory | [Boiling point ]
766.9±60.0 °C(Predicted) | [density ]
1.37±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
9.83±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
Piperidine-GNE-049-N-Boc is a ligand for target protein for PROTAC of dCBP-1 (HY-134582). dCBP-1 is a potent and selective heterobifunctional degrader of p300/CBP[1]. | [Biological Activity]
Piperidine-GNE-049-N-Boc is a ligand for target protein for PROTAC of dCBP-1 (HY-134582). dCBP-1 is a potent and selective heterobifunctional degrader of p300/CBP[1].
Piperidine-GNE-049-N-Boc (S17) can be used for synthesizing dCBP-1[1]. | [References]
[1]. Vannam R, et, al. Targeted degradation of the enhancer lysine acetyltransferases CBP and p300. Cell Chem Biol. 2020 Dec 31;S2451-9456(20)30513-4. |
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