| Identification | Back Directory | [Name]
SB 220025 TRIHYDROCHLORIDE | [CAS]
197446-75-6 | [Synonyms]
SB 220025 trihydrochloride >=98% (HPLC), solid
SB 220025 trihydrochloride,SB220025 trihydrochloride | [Molecular Formula]
C18H19FN6.3ClH | [MDL Number]
MFCD08705333 | [MOL File]
197446-75-6.mol | [Molecular Weight]
447.771 |
| Chemical Properties | Back Directory | [solubility ]
H2O: 22 mg/mL | [form ]
solid | [color ]
white | [Water Solubility ]
H2O: 22mg/mL | [InChI]
1S/C18H19FN6.3ClH/c19-13-3-1-12(2-4-13)16-17(15-7-10-22-18(20)24-15)25(11-23-16)14-5-8-21-9-6-14;;;/h1-4,7,10-11,14,21H,5-6,8-9H2,(H2,20,22,24);3*1H | [InChIKey]
IPFBHUGKKONHFR-UHFFFAOYSA-N | [SMILES]
Cl[H].Cl[H].Cl[H].Nc1nccc(n1)-c2c(ncn2C3CCNCC3)-c4ccc(F)cc4 |
| Hazard Information | Back Directory | [Uses]
SB 220025 trihydrochloride may be used in p38-mediated cell signaling studies. | [Biological Activity]
SB 220025 is a potentspecific inhibitor of human p38 mitogen-activated protein (MAP) kinasewith an IC50 value of 60 nM and 50- to 1000-fold selectivity. SB 220025 reduces inflammatory cytokine production and inhibits angiogenesis. SB 220025 reduced the lipopolysaccharide-induced production of TNF at an ED50 value of 7.5 mg/kg. at 30 mg/kgSB 220025 reduced the expression of TNF and inhibited angiogenesis by ~40%. In a further studythe effects of p38/CSBP MAP kinase inhibition in angiogenesis-dependent chronic inflammatory disease was tested in murine collagen-induced arthritis and SB 220025 was able to prevent the progression of established arthritis. |
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| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
| Company Name: |
SIGMA-RBI
|
| Tel: |
800 736 3690 (Orders) |
| Website: |
www.sigma-aldrich.com |
|